MyBioSource.com's GluA1/GluR1 Monoclonal Antibody is a Mouse monoclonal antibody. The GluA1/GluR1 Monoclonal Antibody was generated using GRIA1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Western Blot.
Description
Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) plays a key role in altering excitatory synaptic transmission in the CNS. Interestingly, the regulatory mechanisms differ between distinct subunits of AMPAR, which range from glutamate receptor 1 (GluR1) to GluR4 (also referred to as GluA1-4). For example, subunits with a long intracellular carboxy terminus (i.e., GluR1, GluR2L, and GluR4) are involved in activity-dependent synaptic targeting of AMPAR, whereas those with a shorter carboxy terminus (i.e., GluR2, GluR3, and GluR4s) seem to maintain basal synaptic transmission. GluR1 has several phosphorylation sites on the intracellular carboxy terminus. Many of these sites have been demonstrated to play a role in synaptic AMPAR regulation and synaptic plasticity